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Add neonatal_wt dataset (neonatal weight progression) - #10

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neonatal-wt-data
Jul 10, 2026
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Add neonatal_wt dataset (neonatal weight progression)#10
mattfidler merged 1 commit into
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neonatal-wt-data

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Adds the neonatal_wt dataset: longitudinal neonatal body weight for 189 neonates (1120 observations) with 5 covariates (Sex, DelM, GA, Mage, Para2).

This is the second case study in Rohleff et al. (2025) on VAE-based nonlinear mixed-effects modeling, used to validate the new est="vae" method in nlmixr2est. Body weight follows a turnover (zero-order production, first-order elimination) growth model whose initial weight is an estimated parameter, so there is no dosing and every record is an observation (EVID=0).

  • data/neonatal_wt.rda (nlmixr2-formatted: ID, TIME, DV, EVID, Sex, DelM, GA, Mage, Para2)
  • R/data_neonatal_wt.R + generated man/neonatal_wt.Rd

🤖 Generated with Claude Code

https://claude.ai/code/session_01CWzfXji5F2nmr34AUa7Ntu

Longitudinal neonatal body weight for 189 neonates (1120 obs) with 5 covariates
(Sex, DelM, GA, Mage, Para2), the second case study in Rohleff et al. (2025) on
VAE-based NLME modeling. No dosing (turnover growth model with an estimated
initial weight), so every record is an observation (EVID=0).

Co-Authored-By: Claude Opus 4.8 <noreply@anthropic.com>
Claude-Session: https://claude.ai/code/session_01CWzfXji5F2nmr34AUa7Ntu
@mattfidler
mattfidler merged commit d667063 into main Jul 10, 2026
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@billdenney
billdenney deleted the neonatal-wt-data branch July 28, 2026 13:46
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